【Abstract】 Objective To study the technique to control rodents in sewers of urban residential areas. Methods Contrast experiment was done in urban residential areas of Wuhan city. Wax block baits was hanged in the sewers according to operating instruction for 6 weeks in the tested areas, while no control measure was taken in the control. The infestation rate of rodents was investigated in the sewer before and after taking control measure. Results The average rodent density was 68.5% in the tested areas and control areas before controlling, however, that in the tested areas reached 96.4% after control for 6 weeks, and the relative population index was 3.1. Conclusion It is effective to control rodent according to the operational instruction in the residential areas.